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03/29/12 at 07:48The individuals taking part were all assessed to be at a high risk of heart disease and all had elevated triglyceride levels. They were also taking Statins to reduce cholesterol. Each of them received a dose of fish oil of either 2 gr or 4 gr a day or a placebo. The results revealed that those taking the 4 grams a day of EPA fish oil saw an average reduction of triglyceride levels of 22 percent/had the biggest reduction of triglyceride levels.
Professor Ballantyne also indicated at the annual scientific sessions of the American Heart Association that he thinks the odds of fish oil working are greater than other treatments but acknowledged that no one has carried out a trial specifically on patients with high triglyceride levels.
Amarin has recently announced that it has filed an application with the FDA for marketing approval for AMR101, for treating high triglyceride levels largely as a result of the ANCHOR trial and a similar trial known as the MARINE trial (Multicenter Placebo Controlled Randomised Double Blind 12 week study with an open label extension trial). The MARINE trial involved over two hundred participants with elevated triglyceride levels who were given either 4 g or 2 g a day of AMR101 or a placebo. The results of this study revealed that after 3 months there was a noteable reduction in triglyceride levels when taking Omega 3.
There is no concrete evidence that elevated triglyceride levels actually increases the risk of coronary events and the JELIS trial is currently the only documented evidence that EPA fish oil reduces the risk of coronary events. The about to commence REDUCE IT study will no doubt reveal more.
Just over 9, (...) ,000 of those in the JELIS study received a purified form of EPA which was much the same kind of fish oil as ARM101 along with statins and the rest just had their statins alone. After a follow up over 4 and a half years later, those who were taking a combination of statins and EPA had a reduced incidence of experiencing a major coronary event when compared to those taking statins alone.
A previous study known as the JELIS study (Japan EPA Lipid Intervention Study), involving more than 19, http://www.louisvuittonmalljapan.com/ ,000 individuals some with and some free from heart disease but with high cholesterol levels revealed that those taking statins along with fish oil had a reduced risk of experiencing a major heart event than those who were taking statins alone. Although the JELIS study didn't concentrate specifically on individuals with high triglyceride levels, but on those with high cholesterol levels, http://www.nikeeamakkusujp.com/ , the results did indicate that fish oil had a protective effect on coronary events.
The results of this came from the ANCHOR trial, (...) , which was a study sponsored by Amarin, the company which is developing AMR101 a highly purified form of EPA fish oil.The Anchor trial involved individuals who were older (average age 61). Around 73 percent had diabetes, (...) , 30 percent were on a "high" efficacy statin regimen, http://www.guccibagsenduring.com/ , 68 percent were on a "medium" efficacy regimen and 7 percent were on a "low" efficacy regimen.
According to Professor Ballantyne, who says he already prescribes EPA fish oil to some of his patients, plenty of studies over many years have shown fish oil to be well tolerated and safe to use with very few side effects.
Amarin is about to begin the clinical end point trial REDUCE IT (Reduction of Cardiovascular Events with EPA Intervention Trial) which will run for about 6 years. This trial will involve approximately 8,000 peopl with elevated triglyceride levels. The results of this trial will give a clearer indication of the benefits of EPA fish oil for reducing cardiac events.
The results revealed that those who had the highest triglyceride levels at baseline and who were on the high efficacy regimen had the most significant reductions in triglyceride levels. The real health benefits from a reduction in triglyceride levels won't be clear until the results come in from a longer study that is only just starting said Professor Christie Ballantyne from the Baylor College of Medicine in (...) articles：
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